Yes. - it's as simple as the title:

The behavior of static methods can be changed just like any other method with Isolator:

With Isolator, you can create fake instances of classes that are sealed or have private constructors, or that are abstract. You just use the same syntax to instantiate them as you ...

with Isolator you can change the behavior of future instances of a specific type (or all instances of that type), by creating your own fake object of that type, setting its ...

With Isolator, you can instantiate a class and control the behavior of constructors down the inheritance chain: You can also control disable static constructors:

Isolator has full support for changing the behavior of methods that are not publicly callable (private, protected, internal):